Developmental fate and lineage commitment of singled mouse blastomeres
نویسندگان
چکیده
منابع مشابه
Developmental fate and lineage commitment of singled mouse blastomeres.
The inside-outside model has been invoked to explain cell-fate specification of the pre-implantation mammalian embryo. Here, we investigate whether cell-cell interaction can influence the fate specification of embryonic blastomeres by sequentially separating the blastomeres in two-cell stage mouse embryos and continuing separation after each cell division throughout pre-implantation development...
متن کاملDevelopmental Bias in Cleavage-Stage Mouse Blastomeres
BACKGROUND The cleavage-stage mouse embryo is composed of superficially equivalent blastomeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (TE). However, it remains unsettled whether the contribution of each blastomere to these two lineages can be accounted for by chance. Addressing the question of blastomere cell fate may be of practical importa...
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Blastomeres of the early mouse embryo are thought to be equivalent in their developmental properties at least until the eight-cell stage. However, the experiments that have led to this conclusion could not have taken into account either the spatial origin of individual blastomeres or the spatial allocation and fate of their progeny. We have therefore readdressed this issue having defined cell l...
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Background “Inside-Outside” hypothesis Cells located on the inside of the 16-cell morula differentiate into the inner cell mass (ICM) of the blastocyst while cells on the outside of the morula differentiate into the trophectoderm (TE) If a cell were moved to a different location in the morula, it would differentiate into a different kind of cell Hypothesis and corollary assumed that, for a time...
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Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic reg...
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ژورنال
عنوان ژورنال: Development
سال: 2012
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.086454